When the body has adjusted to a substance and incorporates the use of that substance into the normal functioning of the body's tissue, it is known as physical dependence.
Physical dependence can be developed due to low-dose therapeutic use of certain medications such as opioids, antidepressants etc.
Dependence is when body gets used to the effects of a drug and goes into withdrawal if you stop using that substance while addiction is classified as a disease.
It is almost impossible to stop using drugs or alcohol once you build up a physical dependence. Few symptoms include anxiety, fatigue, seizures etc.
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