A patient with gastroesophageal reflux disease (gerd) is to begin taking oral metoclopramide [reglan]. the patient asks the nurse about the medication. which response by the nurse is correct?

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19-08-2022
Medicine

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A patient with gastroesophageal reflux disease (gerd) is to begin taking oral metoclopramide [reglan]. the patient asks the nurse about the medication. which response by the nurse is correct?

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tushargupta0691 tushargupta0691 · Answer 1 · 2022-09-01T15:26:31+02:00

A patient with gastroesophageal reflux disease (GERD) is to begin taking oral metoclopramide [reglan] the patient is advised by the nurse to take the medicines 30mins before each meal &amp bedtime.

Metoclopramide should not be used for an extended period of time, and increasing the dose after three months is not advised.

Metoclopramide is a medication used to treat hiccups; it does not produce them.
Tardive dyskinesia is a severe and permanent adverse effect.

What is the mechanism of action of metoclopramide?

Metoclopramide works as an antiemetic by blocking dopamine D2 and serotonin 5-HT3 receptors in the chemoreceptor trigger zone (CTZ), which is located in the brain's postrema region.

This medication causes prokinetic effects via inhibiting presynaptic and postsynaptic D2 receptors, agonism of serotonin 5-HT4 receptors, and antagonism of muscarinic receptor inhibition.
This effect increases acetylcholine release, resulting in enhanced lower oesophagal sphincter (LES) and gastric tone, hence expediting gastric emptying and transit into the gut.
Metoclopramide inhibits dopamine D2 receptors.

Learn more about metoclopramide here,

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